For those who meet the DSM criteria for depression who have tried at least two different classes of traditional antidepressants and found them to be ineffective, the recommended initial “Induction Series” of six low-dose ketamine infusions is administered in an effort to break the cycle. Most clinical trials have consistently shown a 70% success rate with this approach. The treatment does require booster infusions as time passes to keep the effect going. These single “booster infusions” are given at varied intervals for the same 40-60 minute duration, but are single infusions rather than in a series. However, at Altasano, depending on your experience while receiving a ketamine infusion for treatment resistant depression (TRD), we may progressively increase or decrease the doses outside of the “NIH Protocol” in order to optimize the experiential therapeutic effect of Ketamine.