Insurance companies do not pay for medications that are given for “off-label use”. Research on Ketamine in the early 1960’s led to the FDA approval of Ketamine for anesthetic use. Further research on Ketamine in the 1990s began to focus attention on its therapeutic benefits on the treatment of depression and chronic pain. “Off-Label” use of a medicine is legal, but because Ketamine is being used for something else other than what it was originally studied to do, insurance does not cover the cost. Many studies are underway, but currently the FDA has not approved Ketamine for the treatment of depression.